70% of drug molecules face problems of poor bioavailability and instability. Etoposide is a commonly used molecule to treat several cancers, which faces those problems and usual side effects. Nanotechnology applied to medicine can provide important progress, offently by improving bioavailability and dose optimization. Researchers propose here a new formulation of etoposide, excipient-free and based on nanocrystals, improving biodisponibility & dose efficacy. POC in vivo has been established, along with PK and tissue distribution showing improved performance compared to standard Toposar formulation.
Etoposide - Cancer - Formulation Excipient-free formulation - Biodisponibility