Erythrocyte disorders such as sickle cell disease and hereditary spherocytosis represent a growing public health challenge due to the increasing diversity of the French population. Ektacytometry, the reference technique for measuring erythrocyte deformability, has intrinsic technical limitations: it measures the average deformability of red blood cell populations without capturing cellular heterogeneity, and its cost remains high. To overcome these challenges, the inventors have developed a method based on molecular rotors whose fluorescence emission is correlated to red blood cell rigidity. This technology can quantify both single-cell rheology and the mechanical heterogeneity within cell populations, a key parameter in determining the severity of erythrocyte disorders. This innovative approach aims to improve the diagnosis of membrane disorders pathologies and the prognosis of both sickle cell-anemia and spherocytosis.
WO2020/249823
Drepanocytosis - Spherocytosis - Red blood cell - Ektacytometry - Molecular rotor
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