Idiopathic Nephrotic Syndrome (INS) accounts for 85% of glomerular nephropathies in children and 25-30% of those
in adults. Pathogenesis of this syndrome is based on an immune disorder whose mechanism remains incompletely
understood. The team has identified a promising protein target to develop gene therapy for INS. However, no simple
technique compatible with a gene therapy treatment has shown efficiency to target the podocyte so far. Vectors
classically used in gene therapy (adenovirus, retrovirus, etc.) do not allow for proper targeting of the podocyte due
to the presence of a glomerular barrier. Thus, the inventors have developed nanocapsules consisting of multilayers
of chitosan/DNA assembly as a vector carrier allowing specific expression of miRNA in podocytes. This therapeutic
approach has been validated in vitro and optimized for in vivo use, making it possible to envisage new therapeutic
perspectives for INS in humans. This new innovative expression nanocapsule can be optimized for other therapeutic uses.

New heat exchanger based on low cost material, easy to install and maintain. It is based on a flexible polymer tructure and left free in a moving external fluid. 

Therapeutic extracellular vesicles, derived from HEK293T cells expressing the NFAT3 transcription factor, are used in the advanced treatment of metastatic triple-negative breast cancer and pancreatic cancer.

Spacetime-constrained oblivious transfer (SCOT) is a cryptographic task extending one-out-of-m oblivious transfer (OT) by guaranteeing security from quantum physics and relativistic signalling constraints.

Use of anti-miRNAs as therapeutic tools in HER2+ breast cancer.

Compounds releasing carbon monoxide (CO-RMS) are being investigated as a new treatment approach to mitigate age-related metabolic dysfunction.

New optimization algorithm based on fractal decomposition. Thanks to a new approach of covering space this algorithm can solve problems with a large number of variables while providing an exact answer. All this with a very low complexity (logarithmic).

Automated (unsupervised) subsequence anomalies detection in a time series

A new formulation excipient-free and based on nanocrystals, improving biodisponibility & dose efficacy. The first indication developed for this technology is a new formulation of Etoposide, a commonly used molecule to treat several cancers.