PICKERING EMULSION-BASED EYE DROP

Current treatment of glaucoma contain preservative or non-particular surfactant that display deleterious effects (allergy, inflammation). To address this issue the inventors propose a novel ophthalmic composition, comprising a nonionic oil-in-water emulsion (Pickering emulsion), and stabilized with organic nanoparticles. Those innovative ophthalmic compositions could encapsulate active principles with poor solubility in water (steroïds and prostaglandins) and could ensure an ocular extended release. These compositions are useful as a drug, in particular for ocular instillation of drugs involved in treatments of inflammation and glaucoma.

Applications 

• Eye drop formulation for lipophilic active principles (corticoids and prostaglandins
• Dry eye
• Ocular inflammation
• Glaucoma

Competititve advantages

• Free of non-particulate surfactant and preservative.
• Highly stable at room temperature
• Utilization of lipid globules to restore the tear film lipid layer.
• Encapsulation of lipophilic active principles (steroids and prostaglandins)
• Innovative method for preparing high quality emulsions

Intellectual property 

WO2025/056789

Key words

Ophthalmic composition - Nonionic oil-in-water emulsion - Non-particular surfactant - Pickering emulsion - Organic nanoparticles - Preservative