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Activated carbon regeneration
Chimie
Ecologie & environnement
Métaux & minéraux
Chimie, matériaux & produits alimentaires
02/02/2024

REGENERATION OF ACTIVATED CARBON FIBERS AND GRAINS USING AN IN-SITU ELECTROCHEMICAL PROCESS

The development of efficient water filtration systems is an important challenge for environmental engineering. Activated carbon is widely used for the adsorption of organic pollutants, such as pesticides, pharmaceutical by-products and volatile organic compounds. However, it is only a separation step and the regeneration processes of the adsorption material currently present some important drawbacks. A new electrochemical process for in-situ regeneration of activated carbon has been developed. Both adsorption and regeneration steps are performed in the same reactor. The objective of electrochemical regeneration is to recover the adsorption capacity of the adsorption material and to degrade organic pollutants. The technology was initially developed using activated carbon fibers, a breakthrough material allowing faster adsorption of organic pollutants. The technology is also applied for the regeneration of conventional activated carbon grains.

RELATIVISTIC QUANTUM CRYPTOGRAPHY
Physique
Sciences pour l’ingénieur
STIC
Electronique & sécurité
STIC
Services financiers & services aux entreprises
30/01/2024

RELATIVISTIC QUANTUM CRYPTOGRAPHY

SCOT is performed by two mistrustful parties, Alice and Bob. Alice inputs secret messages and Bob obtains a message of his choice in a first spacetime region, i.e, at a particular location and at a particular time. The security conditions are : Alice must be oblivious to Bob’s chosen message, and Bob must be oblivious to the other messages of Alice at spacetime regions that are spacelike separated from the first spacetime region. This technology provides methods and systems to implement unconditionally secure SCOT based on quantum physics and the principle of no-superluminal signalling of special relativity, evading Lo’s no-go theorem for one-out-of-m OT.

EV-MIME
Biologie & santé
Santé
12/12/2023

EV-MIME

Des vésicules extracellulaires (EV) sont produites à partir de cellules HEK293T qui 1) expriment fortement NFAT3, un facteur de transcription qui inhibe la motilité des cellules cancéreuses et 2) sont chargés avec une combinaison de miRNAs qui inhibe la croissance tumorale et la motilité cellulaire. L’évaluation in vitro a révélé que ces EV diminuent de manière significative (80%) la capacité invasive de lignées cellulaires de cancer du sein triple négatif (MDA-MB-231, SUM-59PT) et pancréatiques (BXPC3, MIA-PACA-2). Ces résultats ont été confirmé in vivo dans un modèle murin de cancer du sein triple négatif.

DISRUPTIVE METHOD FOR DIAGNOSING THE STATE OF HEALTH OF POWER ELECTRONICS DEVICES
Physique
Sciences pour l’ingénieur
Aérospatial & défense ...
  • Electronique & sécurité
  • Energie & systèmes électriques
  • Mesures & instrumentation
  • Produits de grande consommation
Automatismes industriels ...
  • Electronique & sécurité
  • Energie & systèmes électriques
  • Mesures & instrumentation
  • Produits de grande consommation
Automobile & transport ...
  • Electronique & sécurité
  • Energie & systèmes électriques
  • Mesures & instrumentation
  • Produits de grande consommation
20/11/2023

DISRUPTIVE METHOD FOR DIAGNOSING THE STATE OF HEALTH OF POWER ELECTRONICS DEVICES

Current methods for monitoring the health status of power semiconductor components, in real time, in operating electronic equipment, are very complex and therefore expensive to implement. Thanks to the discovery of a new unique temperature-independent aging indicator it has now become very simple and economical to diagnose the state of health of these components. The result is a drastic reduction in the cost of maintenance that opens the way to new fields of application previously unthinkable.

ENHANCED RAW EARTH MATERIAL FOR COMPRESSED EARTH BLOCKS CONSTRUCTION
Chimie
Ecologie & environnement
Espace, environnement & société
Chimie, matériaux & produits alimentaires
Environnement & construction
09/11/2023

ENHANCED RAW EARTH MATERIAL FOR COMPRESSED EARTH BLOCKS CONSTRUCTION

Reducing the environmental footprint of building materials is a major challenge in the construction industry. This innovative process makes it possible to reinforce a wide range of excavated soils by making them suitable for raw earth construction. Compressed earth blocks possessing enhanced mechanical properties and water resistance are fabricated with addition of biopolymers. These clay materials, 100% geo-based and bio-based, are an ideal solution for building the city of tomorrow.

DIAGNOSIS AND/OR PROGNOSIS OF HER2+ CANCER USING ONE OR MORE MIRNA AS BIOMARKERS
Biologie & santé
Santé
25/09/2023

DIAGNOSIS AND/OR PROGNOSIS OF HER2+ CANCER USING ONE OR MORE MIRNA AS BIOMARKERS

About 25% of primary human breast cancers are due to the deregulated expression of ErbB2/HER2. HER2-targeted therapies have improved patient survival, but both de novo and acquired resistance remain a challenge, as only 25% of treated patients respond to the current therapies. Equivocal HER2 status also remains an issue as it affects subsequent clinical management. Following the analysis of the expression level of more than 800 miRNA in several human breast cancer cells and patient biopsies with various HER2+ status, the team has identified novel miRNA biomarkers for the diagnosis and prognosis of HER2+ cancers. This allows for further stratification of patients and offers new therapeutic strategies based on the modulation of some of these miRNA. The team has the expertise and know-how required to measure miRNA and HER2 expression levels in biological samples as well as to assess HER2 activation status, downstream signaling and functional effects on cell proliferation and survival in breast cancer.

TREATMENT OF HER2-DEPENDENT CANCER USING AN AGENT THAT MODULATES THE ACTIVITY OF A MIRNA
Biologie & santé
Santé
25/09/2023

TREATMENT OF HER2-DEPENDENT CANCER USING AN AGENT THAT MODULATES THE ACTIVITY OF A MIRNA

About 25% of primary human breast cancers are due to the deregulated expression of HER2 which is also found in many cancer types. HER2-targeted therapies have improved patients’ survival but both de novo and acquired resistance remain a challenge, as only 25% of the patients respond to the actual therapies. The team identified some miRNA including hsa miR-200b-3p and hsa-miR-429 from miR-200 family that are upregulated in HER2+ breast cancer cells and tumour samples. Their high level of expression is of bad prognosis for HER2+ breast cancer patients. Some of these miRNAs are also essential for HER2 expression and/or function. This allows to further stratify HER2+ breast cancer patients to offer a personalized treatment based on the modulation of miR-200b or miR-429. The team developed an optimized and vectorized anti-miRNA allowing specific inactivation of miR-429. Efficacy has been demonstrated in vitro in HER2+ cancer models of breast, gastric, ovarian and pancreatic origin as well as in a HER2+ breast cancer cell in ovo xenograft model.

MICROFLUIDIC ASYMMETRICAL FLOW FIELD-FLOW FRACTIONATION
Chimie
Sciences pour l’ingénieur
Biologie & santé
Chimie, matériaux & produits alimentaires
Santé
19/09/2023

MICROFLUIDIC ASYMMETRICAL FLOW FIELD-FLOW FRACTIONATION (μAF4)

Nanomedicine and biotherapeutics are progressively replacing traditional small drug therapeutics. Lipidic nanoparticles for covid vaccines is one of the most recent and succesful example. The field success is strongly related to analytical techniques such as SEC chromatography and size analysis. AF4 flow separation is an attractive alternative to SEC to separate a wider range of nanoparticles. Yet, the experimental complexity and resources it requires limit its current capacities. Thanks to our expertise in thermoplastic, we can miniaturize it, intensifying its performances and overcoming its current limitations.

Microbiote intestin
Biologie & santé
Santé
19/09/2023

CO-MBACT-AGE

Corroborating evidence supports that intestinal dysbiosis is key to the development of a variety of metabolic, inflammatory, and autoimmune disorders, such as obesity, type 1 and type 2 diabetes, rheumatoid arthritis, inflammatory bowel disease and cancer. Dysbiosis is characterized by an imbalance in bacterial composition, changes in bacterial metabolic activities and/or changes in bacterial distribution within the gut. Our technology consists of using a therapeutically active compound (CO-RM) that interacts with the gut microbiota by delivering controlled amount of carbon monoxide (CO) in vivo, as this endogenous gas is known to exert anti-inflammatory actions and modulate energetic metabolism. We report that gut dysbiosis induced by obesity in mice fed a high fat diet is prevented by oral administration of CO-RM leading to a reduced body weight gain, improved glucose metabolism and increased insulin resistance. The impaired gut dysbiosis in obese mice is exemplified by a marked decrease in the abundance of beneficial bacteria, such as Akkermansia muciniphila, and the ability of CO-RM to restore the impaired microbiota composition (see Figure). Our data provide strong evidence on the efficacy of CO-RM in the treatment of obesity by reprogramming the gut microbiota to a healthy phenotype, indicating that CO might be equally effective against other dysbiosis-associated diseases.

SYNTHÈSE DE NANOCRISTAUX SANS RISQUE DE DISSÉMINATION
Chimie
Chimie, matériaux & produits alimentaires
Environnement & construction
25/04/2023

SYNTHÈSE DE NANOCRISTAUX SANS RISQUE DE DISSÉMINATION

Les revêtements autonettoyants ou réflectifs (textiles, peintures, verres, bétons…) à base de TiO2 sont déjà connus mais le problème majeur reste la taille nanométrique des particules d’oxyde de titane jugée dangereuse pour les êtres vivants. Dans les procédés existants, ces nanocristaux d’oxyde de titane, une fois synthétisés ou achetés, sont importés à l’intérieur ou sur la surface des revêtements. Le risque de dissémination dans l’environnement est donc réel puisque ces particules peuvent se décrocher aisément, de par le lien très faible entre revêtement et matériaux. Notre innovation permet quant à elle d’éviter cette problématique en rendant le lien entre support et TiO2 très fort en développant directement les cristaux à l’intérieur ou sur la surface d’un support sans risque de se décrocher et se disséminer dans l’environnement.

Red blood cell
Biologie & santé
Santé
16/11/2022

CELL-FREE PRODUCTION OF RHESUS BLOOD GROUP ANTIGENS

Red blood cell (RBC) allo-immunization is the immune response of an individual to foreign RBC antigens not present on the surface of their own cells. An efficient detection of alloantibodies is of major interest to manage transfusions in regularly transfused patients, or for the pregnancy follow-up in the context of haemolytic disease of the foetus and new-born (HDFN). However, The Rh blood group system is one of the most polymorphic and immunogenic system, defined by least 54 Rh antigens, some of which being very rare in the population. To date, available commercial test cell reagents, composed of red cell panels expressing different Rh phenotypes, are able to encompass only few of these Rh specificities. Researchers have developed a cell-free system for the production of RH proteins, allowing to obtain large quantities of these proteins in their native state. The method, validated on RhD and RhD-RhAG antigens, relies on the use of in-house assembled nanodiscs, able to incorporate membrane proteins, preserving not only the solubility but also the conformation of newly synthetized membrane proteins. This is to date the first method allowing to generate in vitro Rh antigens with a correct conformation and, thus, ready to be tested by several antibodies, thereby representing a new approach for diagnostic in hematology laboratories investigations.

NEW CELLULAR BIOMARKER OF COVID SEVERITY
Biologie & santé
Santé
15/09/2022

NEW CELLULAR BIOMARKER OF COVID SEVERITY

In attempting to measure SARS-CoV-2 RNA in patients’ blood, the inventors observed that RNase P RNA, a ubiquitous and aspecific human intracellular RNA marker used as an internal control, was strongly correlated with disease severity and intubation status in COVID-19 hospitalized patients with a 5-fold difference in median concentration when comparing critical cases to healthy subjects. Moreover, strong correlation between the event of death and plasmatic RNase P concentration at hospital admission permitted the determination of a concentration threshold that could allow the use of this quantitative plasmatic biomarker as a prognosis tool in COVID-19 hospitalized patients in complement to conventionally collected clinical parameters. These observations reflect the impressive clinical value of plasma RNase P RNA as a surrogate biomarker of COVID-19-induced global cell/tissue damage and the severity of COVID-19 pathology. Three cohorts involving a total of more than 429 patients were evaluated.

SEVERITY & PROGNOSTIC BIOMARKER IN SARS-COV2 PATIENTS
Biologie & santé
Santé
15/09/2022

SEVERITY & PROGNOSTIC BIOMARKER IN SARS-COV2 PATIENTS

The Research Team showed that the level of circulating SARS-CoV-2 viral load increased with the severity of COVID-19 and the proportion of detectable SARS-CoV-2 RNAaemia significantly correlated with the severity of the disease. Based on this, the inventors provide a method for determining a subject’s risk of developing or exhibiting worsening of SARScoronavirus-induced acute pulmonary failure and/or systemic damage, which comprises measuring by RT-PCR the amount of circulating coronavirus RNA (RNAaemia) in a sample from the subject, the sample being a blood, plasma or serum sample. The invention also relates to a method of classifying or following-up (under treatment) a subject infected with SARS coronavirus, which method comprises measuring the amount of coronavirus RNA circulating in a sample of the subject, the sample being a blood, plasma or serum sample from the subject. Three cohorts involving a total of more than 429 patients were evaluated.

INNOVATIVE TRAINING MODULES IN OBSTETRICAL EMERGENCIES
Biologie & santé
Education
Santé
02/09/2022

INNOVATIVE TRAINING MODULES IN OBSTETRICAL EMERGENCIES

Prematurity is the leading cause of death in children under five; each year, approximately 15 million babies are born prematurely all over the world. Prematurity exposes the child and the mother to an increased risk of morbidity and death when the caregivers are not trained in specific care. The research team has developed 2 innovative training modules for training in obstetrical emergencies. The first module is a uterine cervix module created to simulate different configurations of cervical effacement. This automated training tool will allow the simulation of emergency or daily clinical situations related to pregnancy, in particular the threat of premature delivery. The second module is a 3D printed “uterine body”. The training module reproduces different scenarios to treat hemorrhages during childbirth (suture, intrauterine tamponade balloon) in order to improve professional practices and reduce maternal morbidity and mortality.

drone
Mathématiques
STIC
Aérospatial & défense
Mesures & instrumentation
Produits de grande consommation
02/09/2022

MULTI-IMAGE SUPER RESOLUTION AND NOISE REMOVAL FOR EMBEDDED IMAGING

Multi-image fusion is a good solution for performing super-resolution and denoising images, especially for low-cost image capture systems. However, in embedded systems such as satellites, drones or smartphones, the lightweight
embedded processing can be problematic. The innovative process optimizes the distribution of the computational load between the light-embedded processing device and the remote processing solution with a more powerful server. It can also considerably reduce the quantity of data to be transmitted or increase the quality of the result obtained for an equal quantity of data transmitted.

DNA
Biologie & santé
Santé
02/09/2022

METHOD FOR DETERMINING LEVEL OF DNA INTEGRITY

Assessing DNA integrity is a crucial step to characterize the quality of biological samples prior to in-depth genomic analysis, especially applicable in reproductive medicine, prenatal diagnosis and cancer research. Although many methods have been proposed for the assessment of DNA integrity (by electrophoresis, quantitative PCR and, more recently, microfluidic-based procedures), there is still a need to apply more sensitive and precise methods. The invention relates to a method for determining the level of integrity of DNA molecules in a sample containing DNA by multiplexing Digital PCR, which involves amplifying DNA fragments from the sample with amplification primers designed to produce different and predetermined sizes of overlapping amplicons of the same DNA target region, and oligonucleotide probes which can produce detectable and differential signals upon hybridization. Proof of concepts in two main applications have been carried out to date on human clinical samples (small cohort studies):
- By evaluating the ability of the developed clinical trial to discriminate plasma DNA samples from healthy subjects (n=25) and cancer patients (colorectal cancer (n=23), gastric cancer (n=22), pancreatic cancer (n=11))
- By evaluating the quality of DNA after storage in different blood collection tubes

PULMONARY VENTILATION REGIONALIZATION OPTIMIZATION DEVICE BY TITRATION EXTRATHORACIC POSITIVE PRESSURE
Biologie & santé
Santé
02/09/2022

PULMONARY VENTILATION REGIONALIZATION OPTIMIZATION DEVICE BY TITRATION EXTRATHORACIC POSITIVE PRESSURE

Lung injury is not homogeneous because lesions are frequently distributed in the posterior regions. This exposes the lungs to inhomogeneous ventilation under mechanical ventilation with risk of overdistension of the anterior and
cyclic opening-closing of the posterior regions. These two phenomena can aggravate lung damage and lead to excess mortality. Today, no technical solution allows the homogenization of the pulmonary aeration except the prone position. The research team develops «STRAPVENT», a device whose objective is to apply a titrated compression on the compliant anterior chest wall of the thorax. This device allows a more homogeneous distribution of ventilation, protecting the anterior areas from overdistension and favoring the redistribution of ventilation towards the posterior regions. Dramatic improvement in the airways mechanics has been reported in patients with ARDS.

DEVICE FOR SELECTIVELY REGIONALIZING THE VENTILATION OF LUNGS BY EXTRATHORACIC NEGATIVE PRESSURE
Biologie & santé
Santé
02/09/2022

DEVICE FOR SELECTIVELY REGIONALIZING THE VENTILATION OF LUNGS BY EXTRATHORACIC NEGATIVE PRESSURE

60% of patients admitted to intensive care are ventilated by mechanical ventilation to ensure stability and survival. These patients suffer from lesions induced by various pathologies. Lesions located in the alveoli are not evenly distributed, especially in the less compliant posterior lobes. Today, no technical solution allows a re-homogenization of this ventilation. The research team develops «VacuoVent», a device in the form of a bespoke rigid or semi-rigid thoracic shell allowing the application of an extra-thoracic negative pressure on the thoracic wall in front of the damaged lung. This device allows a more homogeneous distribution of ventilation, and is currently being evaluated on cadavers. Next step: the clinical POC.

OPTICAL IMAGING AGENT FOR GUIDED-SURGERY
Biologie & santé
Santé
30/08/2022

OPTICAL IMAGING AGENT FOR GUIDED-SURGERY

While surgery is the main line of treatment for most solid tumors, incomplete tumor resection frequently occurs and represents an additional risk for relapse. The main challenge for surgeons is then to distinguish the surgical boundary between the lesion and the surrounding healthy tissues in an accurate manner. The research team has developed a new specific imaging agent emitting in the tissue transparency zone and targeting E-selectin, a well-known inflammation marker frequently overexpressed in several solid cancers. The imaging agent is capable to specifically detect colorectal tumor in vivo in a mouse xenograft model. This new agent can be used with portable optical imaging systems in the operating room to delineate tumor areas in order to assist surgeons in real time during resection.

BETIC
Chimie
Ecologie & environnement
Environnement & construction
Chimie, matériaux & produits alimentaires
14/06/2022

BETIC

A new biomass conversion process producing biofuels at low temperature. Titanium dioxide crystal clusters are combined with green wastes in water creating a photo catalyst-feedstock pair. The total degradation of the green wastes occurs during exposure to visible light irradiation through TiO2 photo catalysis. After this step, the products are collected and the recovered aqueous TiO2 is combined with new green wastes to form a new feedstock pair, ready for the photocatalytic degradation step. This efficient circular process is a totally solvent-free process.

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