Innovative polymers for membrane protein solubilisation.
A co-exclusive license has been signed between Erganeo and companies Polyscope and Cube Biotech for the development and marketing of two versions of polymers that show improved solubilisation efficiencies of membrane proteins. This technology is of real value in biochemistry and pharmacology
The structural and functional study of membrane proteins can be complex because it is usually only possible once the proteins have been extracted from the biological membranes. In order to do this, scientific teams carry out a solubilisation process to extract these proteins from the cell membranes, which can be done with detergents or amphipathic polymers surfactants[...]
The technology developed by researcher Manuela Zoonens and her team (Université de Paris & CNRS – UMR 7099 Laboratoire de biologie physico-chimique des protéines membranaires) is a research tool based on innovative amphipols that allows direct solubilisation of membrane proteins without the use of detergent. Thus, their extraction is simplified compared with conventional amphipols (A8-35), with a process comprising a single step, free of detergent[...]
This innovation, whose patent was filed by Erganeo in December 2018, was exclusively colicensed on 25 March 2022 to two companies: Orbiscope, powered by Polyscope, a Dutch company specialising in the production and development of polymers, and Cube-Biotech, a German company providing tools and services for membrane protein and other research. An initial version of polymer (C8) is currently available online, before the marketing of the second version (C2-C6) scheduled for September 2022.